SARS-CoV-2 Spike Protein (AA 910-988)

N° du produit ABIN7669678

Cette protéine Recombinant SARS-CoV-2 Spike est produite dans Escherichia coli (E. coli).

Aperçu rapide pour SARS-CoV-2 Spike Protein (AA 910-988) (ABIN7669678)

Antigène: SARS-CoV-2 Spike

Type de proteíne: Recombinant

Activité biologique: Inactive

Origine: SARS Coronavirus-2 (SARS-CoV-2)

Source: Escherichia coli (E. coli)

Pureté: > 95 %

Détail du produit

Attributs du protein: AA 910-988

Fonction: Recombinant SARS-CoV-2 S Protein HR1

Séquence: Gly910-Glu988

Stérilité: 0.2 μm filtered

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: SARS-CoV-2 Spike

Autre désignation: SARS-CoV-2 S

Classe de substances: Viral Protein

Sujet: The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, dipeptidyl peptidase-4, APN, aminopeptidase N, CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1, Sia, sialic acid, O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion, Defines the range of the hosts and specificity of the virus, Main component to bind with the neutralizing antibody, Key target for vaccine design, Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.,SARS-CoV-2 Spike,SARS-CoV-2 Spike Protein

Poids moléculaire:

calculated_mw: 8.4 kDa

observed_mw: 8 kDa

UniProt: P0DTC2